Martin Lohse will coordinate and supervise the project together with other members of the team.

Title Year Authors Journal Links
Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots 2017 Sungkaworn, T., Jobin, M.-L., Burnecki, K., Weron, A., Lohse, M. J., and Calebiro, D. Nature More
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription 2017 Godbole, A., Lyga, S., Lohse, M. J., and Calebiro, D. Nat Comm More
beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle 2016 Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., tobin, A. B., Lohse, M. J., and Hoffmann, C. Nature More
Kinetics and mechanism of G protein-coupled receptor activation 2014 Lohse, M.J., Maiellaro, I., and Calebiro, D. Curr Opin Cell Biol More
Constitutive activation of PKA catalytic subunit in adrenal Cushing’s syndrome 2014 Beuschlein, F., Fassnacht, M., Assié, G., Calebiro, D., Stratakis, C. A., Osswald, A., Ronchi, C. L., Wieland, T., Sbiera, S., Faucz, F. R., Schaak, K., Schmittfull, A., Schwarzmayr, T., Barreau, O., Vezzosi, D., Rizk-Rabin, M., Zabel, U., Szarek, E., Salpea, P., Forlino, A., Vetro, A., Zuffardi, O., Kisker, C., Diener, S., Meitinger, T., Lohse, M. J., Reincke, M., Bertherat, J., Strom, T. M., and Allolio, B. N Engl J Med More
High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy 2014 Sungkaworn, T., Rieken, F., Lohse, M. J., and Calebiro, D. J Vis Exp More
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization 2013 Calebiro, D., Rieken, F., Wagner, J., Sungkaworn, T., Zabel, U., Borzi, A., Cocucci, E., Zurn, A., and Lohse, M. J. Proc Natl Acad Sci USA More
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling 2012 Lohse, M.J., Nuber, S., and Hoffmann C. Pharmacol Rev More
Persistent cAMP signaling by inter- nalized TSH receptors occurs in thyroid but not in HEK293 cells 2012 Werthmann, R. C., Volpe, S., Lohse, M. J., and Calebiro, D. FASEB J More
Comparison of the activation kinetics of the m3 acetylcholine receptor and a constitutively active mutant receptor in living cells 2012 Hoffmann, C., Nuber, S., Zabel, U., Ziegler, N., Winkler, C., Hein, P., Berlot, C. H., Bünemann, M., and Lohse, M. J. Mol Pharmacol More
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1 2012 Hlavackova, V., Zabel, U., Frankova, D., Bätz, J., Hoffmann, C., Prezeau, L., Pin, J. P., Blahos, J., and Lohse, M. J. Sci Signal More
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells 2011 Börner, S., Schwede, F., Schlipp, A., Berisha, F., Calebiro, D., Lohse, M. J., and Nikolaev, V. O. Nat Protoc More
Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary 2010 Jacobs, S., Calebiro, D., Nikolaev, V. O., Lohse, M. J., and Schulz, S. Endocrinology More
Fluorescent labeling of tetracysteine-tagged proteins in intact cells 2010 Hoffmann, C., Gaietta, G., Zürn, A., Adams, S. R., Terrillon, S., Ellisman, M. H., Tsien, R. Y., and Lohse, Nat Protoc More
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors 2009 Calebiro, D., Nikolaev, V. O., Gagliani, M. C., de Filippis, T., Dees, C., Tacchetti, C., Persani, L., and Lohse, M. J. PLoS Biol More
Fluorescence Resonance Energy Transfer Analysis of {alpha}2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes 2009 Zürn, A., Zabel, U., Vilardaga, J. P., Schindelin, H., Lohse, M. J., and Hoffmann, C. Mol Pharmacol More
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling 2008 Vilardaga, J. P., Nikolaev, V. O., Lorenz, K., Ferrandon, S., Zhuang, Z., and Lohse, M. J. Nat Chem Biol More
Molecular Basis of Partial Agonism at the Neurotransmitter {alpha}2A-Adrenergic Receptor and Gi-protein Heterotrimer 2006 Nikolaev, V. O., Hoffmann, C., Bünemann, M., Lohse, M. J., and Vilardaga, J. P. J Biol Chem More
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells 2005 Hoffmann, C., Gaietta, G., Bünemann, M., Adams, S. R., Oberdorff-Maass, S., Behr, B., Vilardaga, J. P., Tsien, R. Y., Ellisman, M. H., and Lohse, M. J. Nat Methods More
Molecular basis of inverse agonism in a G protein coupled receptor 2005 Vilardaga, J. P., Steinmeyer, R., Harms, G. S. and Lohse, M. J. Nat Chem Biol More
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells 2003 Vilardaga, J. P., Bünemann, M., Krasel, C., Castro, M., and Lohse, M. J. Nat Biotechnol More