Carsten Hoffmann will coordinate and supervise the project together with other members of the team.

Title Year Authors Journal Links
beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle 2016 Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., tobin, A. B., Lohse, M. J., and Hoffmann, C. Nature More
Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor 2014 Bock, A., Chirinda, B., Krebs, F., Messerer, R., Bätz, J., Muth, M., Dallanoce, C., Klingenthal, D., Tränkle, C., Hoffmann, C., De Amici, M., Holzgrabe, U., Kostenis, E., and Mohr, K. Nat Chem Biol More
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling 2012 Lohse, M.J., Nuber, S., and Hoffmann C. Pharmacol Rev More
Comparison of the activation kinetics of the m3 acetylcholine receptor and a constitutively active mutant receptor in living cells 2012 Hoffmann, C., Nuber, S., Zabel, U., Ziegler, N., Winkler, C., Hein, P., Berlot, C. H., Bünemann, M., and Lohse, M. J. Mol Pharmacol More
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling 2012 Bock, A., Merten, N., Schrage, R., Dallanoce, C., Bätz, J., Klöckner, J., Schmitz, J., Matera, C., Simon, K., Kebig, A., Peters, L., Muller, A., Schrobang-Ley, J., Tränkle, C., Hoffmann, C., De Amici, M., Holzgrabe, U., Kostenis, E., and Mohr, K. Nat Commun More
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1 2012 Hlavackova, V., Zabel, U., Frankova, D., Bätz, J., Hoffmann, C., Prezeau, L., Pin, J. P., Blahos, J., and Lohse, M. J. Sci Signal More
Fluorescent labeling of tetracysteine-tagged proteins in intact cells 2010 Hoffmann, C., Gaietta, G., Zürn, A., Adams, S. R., Terrillon, S., Ellisman, M. H., Tsien, R. Y., and Lohse, Nat Protoc More
Fluorescence Resonance Energy Transfer Analysis of {alpha}2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes 2009 Zürn, A., Zabel, U., Vilardaga, J. P., Schindelin, H., Lohse, M. J., and Hoffmann, C. Mol Pharmacol More
Molecular Basis of Partial Agonism at the Neurotransmitter {alpha}2A-Adrenergic Receptor and Gi-protein Heterotrimer 2006 Nikolaev, V. O., Hoffmann, C., Bünemann, M., Lohse, M. J., and Vilardaga, J. P. J Biol Chem More
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells 2005 Hoffmann, C., Gaietta, G., Bünemann, M., Adams, S. R., Oberdorff-Maass, S., Behr, B., Vilardaga, J. P., Tsien, R. Y., Ellisman, M. H., and Lohse, M. J. Nat Methods More